Berberine and its derivatives in collagen matrices as antimicrobial agents

Abstract The combination of collagen with natural plant compounds confers anti-inflammatory, antimicrobial, and antiviral activities to the polymeric material. These favorable properties enable broad-spectrum application traditional, polymers in biomedicine. In present study, fish was combined commercially available berberine (BBR) naturally occurring protoberberine alkaloids obtained from medicinal herb Chelidonium majus L (BBR-F). incorporation constituents into matrices confirmed by Raman spectroscopy. antimicrobial plant-polymeric composites were assessed against typical pathogenic microorganisms ( Staphylococcus aureus , Escherichia coli Candida albicans) . plant-based inhibited growth all studied pathogens. Graphical abstract